Table 4. Resistant Bacteria Encountered in In-Patient Areas of CPMC in 1993

Organism

Resistance to:

Mechanism

Rate of Resistance

Staphylococcus aureus

Penicillins

Methacillin

Fluoroquinolones gyrase

Beta-lactamase
Altered PBPs

Altered DNA

97

10

12, 55

Staphylococcus epidermidis

Penicillins

Methicillin^a

Beta-lactamase
Altered PBPs

70

47

Enterococcus faecium

Ampicillin

Imipenem

Aminoglycosides

Vancomycin receptor

Beta-lactamase
Altered PBP

Inactivating enzymes
Altered enzyme

<1

100

32

?10

Pseudomonas aeruginosa

Antipseudomonas penicillins

Ceftazidime/Aztreonam

Imipenem

Aminoglycosides enzymes

Beta-lactamases

Altered OMP

Altered OMP

Inactivating

38


12

5

26

Klebsiella pneumoniae

3rd generation cephalosporins

Beta-lactamase

4